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Patients presenting with symptoms of acute ischemic stroke who have evidence of large vessel (> 2.5mm in diameter) occlusion in the cerebral circulation will be assigned to either the Penumbra System with the Separator 3D or the Penumbra System without the Separator 3D. The hypothesis to be tested is that the safety and effectiveness of the Penumbra system with the Separator 3D for the revascularization of large vessel occlusion is not inferior to the Penumbra System alone.
A Phase III Randomized Multicenter Clinical Trial of Blood Pressure Reduction for Hypertension in Acute Intracerebral Hemorrhage.
This is a randomized, multi-center, prospective, double blind, two-stage, adaptive study. The primary objective is to demonstrate the efficacy of RP-1127 compared to placebo in subjects with a severe anterior circulation ischemic stroke who are likely to develop malignant edema.
The purpose of this study is to determine whether the combination of thrombolysis and hypothermia is superior to thrombolysis alone for the treatment of ischemic stroke.
A phase III, randomized, case-controlled, open-label, 500-subject clinical trial of minimally invasive surgery plus rt-PA in the treatment of intracerebral hemorrhage (ICH).
A descriptive pilot study that aims to evaluate the changes in the patient’s neurologic and cognitive function following surgical treatment for Moyamoya disease. Pre-treatment and post-treatment evaluations of the patients’ neurologic function and status, cognitive and psychological functioning and imaging studies will be performed. The aim is to gain a better understanding of the cognitive and functional impact of Moyamoya disease after surgical intervention.
The primary objective of this study is to evaluate the rate of stroke and/or death in patients treated with the Wingspan Stent System, according to the Indications for Use, within 72 hours post procedure.
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