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RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving temozolomide alone, radiation therapy alone, or temozolomide together with radiation therapy is more effective in treating anaplastic glioma. PURPOSE: This randomized phase III trial is comparing giving temozolomide alone, radiation therapy alone, or Temozolomide together to see which works best in treating patients with newly diagnosed anaplastic glioma. (NCT00887146)
Radiation therapy uses high energy x rays to kill tumor cells. Lapatinib ditosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet know whether radiation therapy together with lapatinib ditosylate is an effective treatment for brain metastasis from breast cancer. This randomized phase II trial studies how well whole-brain radiation therapy (WBRT) with or without lapatinib ditosylate works in treating patients with brain metastasis from HER2-positive breast cancer.(NCT01622868)
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