- CALGB 70604 - A Randomized Phase III Study of Standard Dosing versus Longer Dosing Interval of Zoledornic Acid in Metastatic Cancer. (Breast Adenocarcinoma, Prostate Adenocarcinoma, Multiple Myeloma).
Zoledronic acid may stop the growth of cancer cells in bone and may help relieve some of the symptoms caused by bone metastases. It is not yet known which schedule of zoledronic acid is more effective in treating patients with metastatic cancer that has spread to the bone. This randomized phase III trial is studying two different schedules of zoledronic acid to compare how well they work in treating patients with metastatic breast cancer, metastatic prostate cancer, or multiple myeloma with bone involvement. (NCT00869206)
- RTOG - 0517 - Randomized Phase III Trial to Evaluate Radiopharmaceuticals and Zoledronic Acid in Palliation of Osteoblastic Metastases from Lung, Breast, and Prostate Cancer.
Zoledronate, vitamin D and calcium may prevent or delay bone pain and other symptoms caused by bone metastases. It is not yet known whether giving zoledronate together with vitamin D and calcium is more effective with or without strontium 89 or samarium 153 in treating patients with bone metastases from prostate cancer, lung cancer, or breast cancer. This randomized phase III trial is studying zoledronate, vitamin D, and calcium to see how well they work compared to zoledronate, vitamin D, calcium, and either strontium 89 or samarium 153 in preventing or delaying bone problems in patients with bone metastases from prostate cancer, lung cancer, or breast cancer. (NCT00365105)
- RTOG 0433 - A Phase III International Randomized Trial of Single versus Multiple Fractions for Re-Irradiation of Painful Bone Metastases.
Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known whether single-fraction (single-dose) radiation therapy is more effective than multiple-fraction reirradiation (many small doses of radiation therapy) in relieving bone pain caused by bone metastases. This randomized phase III trial is studying single-dose radiation therapy to see how well it works compared to multiple-dose radiation therapy in treating patients with painful bone metastases. (NCT000080912)
- RTOG 0631 - Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis.
RATIONALE: Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. PURPOSE: This randomized phase II/III trial is studying how well image-guided radiosurgery or stereotactic body radiation therapy works and compares it to external-beam radiation therapy in treating patients with localized spine metastasis. (NCT00922974)