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Drugs used in chemotherapy, such as azacitidine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. MS-275 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving azacitidine together with MS-275 may kill more cancer cells. This randomized phase II trial is studying azacitidine and MS-275 to see how well they work compared to azacitidine alone in treating patients with myelodysplastic syndromes, chronic myelomonocytic leukemia, or acute myeloid leukemia. (NCT00313586)
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